Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction
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چکیده
منابع مشابه
Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction
The expansion of homopolymeric glutamine (polyQ) or alanine (polyA) repeats in certain proteins owing to genetic mutations induces protein aggregation and toxicity, causing at least 18 human diseases. PolyQ and polyA repeats can also associate in the same proteins, but the general extent of their association in proteomes is unknown. Furthermore, the structural mechanisms by which their expansio...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2014
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddu049